Salcaprozate sodium (SNAC), an oral absorption promoter, serves as a potent delivery agent for oral heparin and insulin by enhancing passive transcellular permeation through small intestinal epithelia. This is achieved through its capability to increase lipophilicity via non-covalent macromolecule complexation.

Salcaprozate sodium（SNAC；12.5-400 μg/mL；24小时）对Caco-2细胞无毒性，并且当SNAC浓度为200 μg/mL时，存活率超过90%。SNAC（50和200 μg/mL）比SAs溶液的Papp提高了RA和SA-B的表观通透系数（Papp）2.14倍和3.68倍[1]。